U-Blot® cdc2 (Phospho Thr14) rabbit pAb

Name: U-Blot® cdc2 (Phospho Thr14) rabbit pAb
SKU: WP10319
Availability: InStock

$288.00

Size:50μL

SKU: WP10319-50

Catalog No.: WP10319

Specification: 50μL/100μL

Stock: In stock

U-Blot® cdc2 (Phospho Thr14) rabbit pAb Learn more

Product details Specifications Q & A Education

Background：cyclin dependent kinase 1(CDK1) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],

Product Overview

Catalog No.: WP10319
SKU: WP10319-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: CDK1/CDC2
Reactivity: Human,Rat,Mouse,
Application: WB
MW(Calculated): --
MW(Observed): 34kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:1000-2000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized phosho peptide around human cdc2 (Thr14)
Sequence: --
Specificity: This antibody detects endogenous levels of Human cdc2 (phospho-Thr14)
Gene Name: CDK1 CDC2 CDC28A CDKN1 P34CDC2
Protein Name: cdc2 (Thr14)
Other Name: Cyclin-dependent kinase 1;CDK1;EC 2.7.11.23;Cell division control protein 2 homolog;Cell division protein kinase 1;p34 protein kinase;
Organism-1: Human
Gene ID-1: 983
SwissProt-1: P06493
Organism-2: Mouse
Gene ID-2: 12534
SwissProt-2: P11440
Organism-3: Rat
Gene ID-3: 54237
SwissProt-3: P39951
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus. Cytoplasm. Mitochondrion . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle. Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.