U-Blot® FoxO3a (Phospho Ser294) rabbit pAb

Name: U-Blot® FoxO3a (Phospho Ser294) rabbit pAb
SKU: WP10358
Availability: InStock

$288.00

Size:50μL

SKU: WP10358-50

Catalog No.: WP10358

Specification: 50μL/100μL

Stock: In stock

U-Blot® FoxO3a (Phospho Ser294) rabbit pAb Learn more

Product details Specifications Q & A Education

Background：This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP10358
SKU: WP10358-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: FoxO3a
Reactivity: Human,Mouse,Rat
Application: WB
MW(Calculated): --
MW(Observed): 90kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:1000-2000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized phosho peptide around human FoxO3a (Ser294)
Sequence: --
Specificity: This antibody detects endogenous levels of Human Mouse Rat FoxO3a (phospho-Ser294)
Gene Name: FOXO3 FKHRL1 FOXO3A
Protein Name: FoxO3a (Ser294)
Other Name: Forkhead box protein O3;AF6q21 protein;Forkhead in rhabdomyosarcoma-like 1;
Organism-1: Human
Gene ID-1: 2309
SwissProt-1: O43524
Organism-2: Mouse
Gene ID-2: 56484
SwissProt-2: Q9WVH4
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm, cytosol . Nucleus . Mitochondrion matrix . Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side . Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, PubMed:15084260, PubMed:16751106). Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, PubMed:16751106). Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity). Translocates in a AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:23283301, PubMed:29445193). Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (By similarity). .