U-Blot® SQSTM1/p62 (Phospho Ser403) rabbit pAb

Name: U-Blot® SQSTM1/p62 (Phospho Ser403) rabbit pAb
SKU: WP10506
Availability: InStock

$288.00

Size:50μL

SKU: WP10506-50

Catalog No.: WP10506

Specification: 50μL/100μL

Stock: In stock

U-Blot® SQSTM1/p62 (Phospho Ser403) rabbit pAb Learn more

Product details Specifications Q & A Education

Background：This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009],

Product Overview

Catalog No.: WP10506
SKU: WP10506-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: SQSTM1/p62
Reactivity: Human,Mouse,Rat
Application: WB,IHC
MW(Calculated): 48kD
MW(Observed): 60kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-300
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized phosho peptide around human SQSTM1 (Ser403)
Sequence: --
Specificity: This antibody detects endogenous levels of Human Mouse Rat SQSTM1/p62 (phospho-Ser403)
Gene Name: SQSTM1 ORCA OSIL
Protein Name: SQSTM1/p62 (Ser403)
Other Name: Sequestosome-1;EBI3-associated protein of 60 kDa;EBIAP;p60;Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa;Ubiquitin-binding protein p62;
Organism-1: Human
Gene ID-1: 8878
SwissProt-1: Q13501
Organism-2: Mouse
Gene ID-2: 18412
SwissProt-2: Q64337
Organism-3: Rat
Gene ID-3: 113894
SwissProt-3: O08623
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm, cytosol . Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Nucleus, PML body . Cytoplasm, myofibril, sarcomere . In cardiac muscle, localizes to the sarcomeric band (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large amounts in Mallory bodies of alcoholic and nonalcoholic steatohepatitis, hyaline bodies in hepatocellular carcinoma, and in SERPINA1 aggregates. Enriched in Rosenthal fibers of pilocytic astrocytoma. In the cytoplasm, observed in both membrane-free ubiquitin-containing protein aggregates (sequestosomes) and membrane-surrounded autophagosomes. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum. Co-localizes with TRIM5 in cytoplasmic bodies. When nuclear export is blocked by treatment with leptomycin B, accumulates in PML bodies. .