U-Blot® SREBP-2 (Phospho Ser455) rabbit pAb

Name: U-Blot® SREBP-2 (Phospho Ser455) rabbit pAb
SKU: WP10695
Availability: InStock

$288.00

Size:50μL

SKU: WP10695-50

Catalog No.: WP10695

Specification: 50μL/100μL

Stock: In stock

U-Blot® SREBP-2 (Phospho Ser455) rabbit pAb Learn more

Product details Specifications Q & A Education

Background：This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Product Overview

Catalog No.: WP10695
SKU: WP10695-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: SREBP-2
Reactivity: Human,Mouse,Rat
Application: WB
MW(Calculated): 126kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human SREBP-2 (Phospho-Ser455)
Sequence: --
Specificity: This antibody detects endogenous levels of SREBP-2 (Phospho-Ser455) at Human, Mouse,Rat
Gene Name: SREBF2 BHLHD2 SREBP2
Protein Name: SREBP-2 (Phospho-Ser455)
Other Name: SRBP2;Sterol regulatory element-binding protein 2;SREBP-2;Class D basic helix-loop-helix protein 2;bHLHd2;Sterol regulatory element-binding transcription factor 2;[Cleaved into: Processed sterol regulatory element-binding protein 2]
Organism-1: Human
Gene ID-1: 6721
SwissProt-1: Q12772
Organism-2: Mouse
Gene ID-2: 20788
SwissProt-2: Q3U1N2
Organism-3: Rat
Gene ID-3: 300095
SwissProt-3: Q3T1I5
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: [Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, COPII-coated vesicle membrane ; Multi-pass membrane protein . At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum (PubMed:32322062). Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed (PubMed:32322062). .; [Processed sterol regulatory element-binding protein 2]: Nucleus . Transported into the nucleus with the help of importin-beta. Dimerization of the bHLH domain is a prerequisite for importin beta-dependent nuclear import. .