U-Blot® TOPBP1 (Phospho Ser1159) rabbit pAb

Name: U-Blot® TOPBP1 (Phospho Ser1159) rabbit pAb
SKU: WP10709
Availability: InStock

$288.00

Size:50μL

SKU: WP10709-50

Catalog No.: WP10709

Specification: 50μL/100μL

Stock: In stock

U-Blot® TOPBP1 (Phospho Ser1159) rabbit pAb Learn more

Product details Specifications Q & A Education

Background：This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP10709
SKU: WP10709-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: TOPBP1
Reactivity: Human,Mouse,Rat
Application: WB
MW(Calculated): 167kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human TOPBP1 (Phospho-Ser1159)
Sequence: --
Specificity: This antibody detects endogenous levels of TOPBP1 (Phospho-Ser1159) at Human, Mouse,Rat
Gene Name: TOPBP1 KIAA0259
Protein Name: TOPBP1 (Phospho-Ser1159)
Other Name: DNA topoisomerase 2-binding protein 1;DNA topoisomerase II-beta-binding protein 1;TopBP1;DNA topoisomerase II-binding protein 1;
Organism-1: Human
Gene ID-1: 11073
SwissProt-1: Q92547
Organism-2: Mouse
Gene ID-2: 235559
SwissProt-2: Q6ZQF0
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX- independent manner. .