U-Blot® NPM (Phospho Ser70) Rabbit pAb

Name: U-Blot® NPM (Phospho Ser70) Rabbit pAb
SKU: WP10774
Availability: InStock

$288.00

Size:50μL

SKU: WP10774-50

Catalog No.: WP10774

Specification: 50μL/100μL

Stock: In stock

U-Blot® NPM (Phospho Ser70) Rabbit pAb Learn more

Product details Specifications Q & A Education

Background：nucleophosmin(NPM1) Homo sapiens This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009],

Product Overview

Catalog No.: WP10774
SKU: WP10774-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Nucleophosmin
Reactivity: Human,Mouse,Rat
Application: IHC,WB
MW(Calculated): --
MW(Observed): 32kD
Host Species: Rabbit
Isotype: --
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-200
Form: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human NPM (Phospho Ser70)
Sequence: --
Specificity: This antibody detects endogenous levels of NPM (Phospho Ser70) Rabbit pAb at Human, Mouse,Rat
Gene Name: NPM1 NPM
Protein Name: Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Other Name: NPM1;NPM;Nucleophosmin;NPM;Nucleolar phosphoprotein B23;Nucleolar protein NO38;Numatrin
Organism-1: Human
Gene ID-1: 4869
SwissProt-1: P06748
Organism-2: Mouse
Gene ID-2: 18148
SwissProt-2: Q61937
Organism-3: Rat
Gene ID-3: 25498
SwissProt-3: P13084
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Can shuttle between cytoplasm and nucleus. Co- localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis.