U-Blot® PAK1 (Phospho Ser21) Rabbit pAb

Name: U-Blot® PAK1 (Phospho Ser21) Rabbit pAb
SKU: WP10811
Availability: InStock

$288.00

Size:50μL

SKU: WP10811-50

Catalog No.: WP10811

Specification: 50μL/100μL

Stock: In stock

U-Blot® PAK1 (Phospho Ser21) Rabbit pAb Learn more

Product details Specifications Q & A Education

Background：p21 (RAC1) activated kinase 1(PAK1) Homo sapiens This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010],

Product Overview

Catalog No.: WP10811
SKU: WP10811-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: PAK1
Reactivity: Human,Mouse,Rat
Application: IHC,WB
MW(Calculated): --
MW(Observed): 61kD
Host Species: Rabbit
Isotype: --
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-200
Form: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human PAK1 (Phospho Ser21)
Sequence: --
Specificity: This antibody detects endogenous levels of PAK1 (Phospho Ser21) Rabbit pAb at Human, Mouse,Rat
Gene Name: PAK1
Protein Name: Serine/threonine-protein kinase PAK 1 (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)
Other Name: Serine/threonine-protein kinase PAK 1;Alpha-PAK;p21-activated kinase 1;PAK-1;p65-PAK;
Organism-1: Human
Gene ID-1: 5058
SwissProt-1: Q13153
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: O88643
Organism-3: Rat
Gene ID-3: 29431
SwissProt-3: P35465
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Cell junction, focal adhesion . Cell projection, lamellipodium . Cell membrane . Cell projection, ruffle membrane . Cell projection, invadopodium . Nucleus, nucleoplasm . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with RUFY3, F-actin and other core migration components in invadopodia at the cell periphery (PubMed:25766321). Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212 where is co-recruited with MORC2 on damaged chromatin (PubMed:23260667). Localization to the centrosome does not depend upon the presence of gamma-tubulin (PubMed:27012601). Localization of the active, but not inactive, protein to the adhesions and edge of lamellipodia is mediated by interaction with GIT1 (PubMed:11896197). .