U-Blot® HECW1 Polyclonal Antibody

Name: U-Blot® HECW1 Polyclonal Antibody
SKU: WP1103
Availability: InStock

$268.00

Size:50μL

SKU: WP1103-50

Catalog No.: WP1103

Specification: 50μL/100μL

Stock: In stock

U-Blot® HECW1 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with DVL1 and SSR3. Also interacts with mutant SOD1.,tissue specificity:Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.,

Product Overview

Catalog No.: WP1103
SKU: WP1103-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: HECW1
Reactivity: Human,Mouse
Application: WB,ELISA
MW(Calculated): --
MW(Observed): 176kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;ELISA 1:5000-20000
Form: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from part region of human protein. AA range: 1-67
Sequence: --
Specificity: HECW1 Polyclonal Antibody detects endogenous levels of protein.
Gene Name: HECW1 KIAA0322 NEDL1
Protein Name: E3 ubiquitin-protein ligase HECW1 (HECT, C2 and WW domain-containing protein 1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)
Other Name: --
Organism-1: Human
Gene ID-1: 23072
SwissProt-1: Q76N89
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q8K4P8
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm .