U-Blot® Atrophin-1 Polyclonal Antibody

Name: U-Blot® Atrophin-1 Polyclonal Antibody
SKU: WP11217
Availability: InStock

$268.00

Size:50μL

SKU: WP11217-50

Catalog No.: WP11217

Specification: 50μL/100μL

Stock: In stock

U-Blot® Atrophin-1 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-35 copies to 49-93 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein. [provided by RefSeq, Jul 2016],

Product Overview

Catalog No.: WP11217
SKU: WP11217-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Atrophin-1
Reactivity: Human,Mouse,Rat
Application: WB,ELISA
MW(Calculated): --
MW(Observed): 130kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;ELISA 1:5000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human ATN1. AA range:81-130
Sequence: --
Specificity: Atrophin-1 Polyclonal Antibody detects endogenous levels of Atrophin-1 protein.
Gene Name: ATN1
Protein Name: Atrophin-1
Other Name: ATN1;D12S755E;DRPLA;Atrophin-1;Dentatorubral-pallidoluysian atrophy protein
Organism-1: Human
Gene ID-1: 1822
SwissProt-1: P54259
Organism-2: Mouse
Gene ID-2: 13498
SwissProt-2: O35126
Organism-3: Rat
Gene ID-3: 29515
SwissProt-3: P54258
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus. Cytoplasm, perinuclear region. Cell junction . Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell-cell junctions and leading edges of cells (By similarity). Colocalizes with MTG8 in discrete nuclear dots. Proteolytic fragment F1 appears to remain in nucleus. Fragment F2 is exported into the cytoplasm. Fragment F2 from mutant sequences with longer poly-Gln (polyQ) tracts are additionally located to the cytoplasmic membrane and to certain organelles. .