U-Blot® FAS-L Polyclonal Antibody

Name: U-Blot® FAS-L Polyclonal Antibody
SKU: WP12277
Availability: InStock

$268.00

Size:50μL

SKU: WP12277-50

Catalog No.: WP12277

Specification: 50μL/100μL

Stock: In stock

U-Blot® FAS-L Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014],

Product Overview

Catalog No.: WP12277
SKU: WP12277-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: FAS-L
Reactivity: Human,Mouse,Pig
Application: WB,IHC,IF,ELISA
MW(Calculated): --
MW(Observed): 33kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:40000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human FAS ligand. AA range:101-150
Sequence: --
Specificity: FAS-L Polyclonal Antibody detects endogenous levels of FAS-L protein.
Gene Name: FASLG
Protein Name: Tumor necrosis factor ligand superfamily member 6
Other Name: FASLG;APT1LG1;CD95L;FASL;TNFSF6;Tumor necrosis factor ligand superfamily member 6;Apoptosis antigen ligand;APTL;CD95 ligand;CD95-L;Fas antigen ligand;Fas ligand;FasL;CD antigen CD178
Organism-1: Human
Gene ID-1: 356
SwissProt-1: P48023
Organism-2: Mouse
Gene ID-2: 14103
SwissProt-2: P41047
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cell membrane ; Single-pass type II membrane protein . Cytoplasmic vesicle lumen . Lysosome lumen . Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290). Colocalizes with the SPPL2A protease at the cell membrane (PubMed:17557115). .; [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted . May be released into the extracellular fluid by cleavage from the cell surface. .; [FasL intracellular domain]: Nucleus . The FasL ICD cytoplasmic form is translocated into the nucleus. .