U-Blot® FGF-1 Polyclonal Antibody

Name: U-Blot® FGF-1 Polyclonal Antibody
SKU: WP12295
Availability: InStock

$268.00

Size:50μL

SKU: WP12295-50

Catalog No.: WP12295

Specification: 50μL/100μL

Stock: In stock

U-Blot® FGF-1 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009],

Product Overview

Catalog No.: WP12295
SKU: WP12295-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: FGF-1
Reactivity: Human,Mouse,Rat
Application: IHC,IF,ELISA
MW(Calculated): 17kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human FGF-1. AA range:7-56
Sequence: --
Specificity: FGF-1 Polyclonal Antibody detects endogenous levels of FGF-1 protein.
Gene Name: FGF1
Protein Name: Fibroblast growth factor 1
Other Name: FGF1;FGFA;Fibroblast growth factor 1;FGF-1;Acidic fibroblast growth factor;aFGF;Endothelial cell growth factor;ECGF;Heparin-binding growth factor 1;HBGF-1
Organism-1: Human
Gene ID-1: 2246
SwissProt-1: P05230
Organism-2: Mouse
Gene ID-2: 14164
SwissProt-2: P61148
Organism-3: Rat
Gene ID-3: 25317
SwissProt-3: P61149
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. .