U-Blot® GANP Polyclonal Antibody

Name: U-Blot® GANP Polyclonal Antibody
SKU: WP12419
Availability: InStock

$268.00

Size:50μL

SKU: WP12419-50

Catalog No.: WP12419

Specification: 50μL/100μL

Stock: In stock

U-Blot® GANP Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014],

Product Overview

Catalog No.: WP12419
SKU: WP12419-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: GANP
Reactivity: Human,Mouse
Application: WB,IHC,IF,ELISA
MW(Calculated): --
MW(Observed): 218kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human GANP. AA range:1841-1890
Sequence: --
Specificity: GANP Polyclonal Antibody detects endogenous levels of GANP protein.
Gene Name: MCM3AP
Protein Name: 80 kDa MCM3-associated protein
Other Name: MCM3AP;GANP;KIAA0572;MAP80;80 kDa MCM3-associated protein;Protein GANP
Organism-1: Human
Gene ID-1: 8888
SwissProt-1: O60318
Organism-2: Mouse
Gene ID-2: 54387
SwissProt-2: Q9WUU9
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: [Isoform GANP]: Nucleus envelope . Nucleus, nuclear pore complex . Nucleus, nucleoplasm . Chromosome . Predominantly located at the nuclear envelope, facing the nucleus interior (PubMed:20005110, PubMed:21195085, PubMed:23591820). Localization at the nuclear pore complex requires NUP153, TPR and ALYREF/ALY (PubMed:23591820, PubMed:22307388). Also found associated with chromatin (PubMed:23652018). In B-cells, targeted to the immunoglobulin variable region genes (PubMed:23652018). .; [Isoform MCM3AP]: Cytoplasm . Nucleus . Translocates into the nucleus in the presence of MCM3 (PubMed:12226073). Associates with chromatin possibly through interaction with MCM3 (PubMed:12226073). .