U-Blot® GFRα-1 Polyclonal Antibody

Name: U-Blot® GFRα-1 Polyclonal Antibody
SKU: WP12464
Availability: InStock

$268.00

Size:50μL

SKU: WP12464-50

Catalog No.: WP12464

Specification: 50μL/100μL

Stock: In stock

U-Blot® GFRα-1 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016],

Product Overview

Catalog No.: WP12464
SKU: WP12464-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: GFRα-1
Reactivity: Human,Mouse,Rat
Application: IHC,IF,WB,ELISA
MW(Calculated): 51kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human GFR alpha-1. AA range:51-100
Sequence: --
Specificity: GFRα-1 Polyclonal Antibody detects endogenous levels of GFRα-1 protein.
Gene Name: GFRA1
Protein Name: GDNF family receptor alpha-1
Other Name: GFRA1;GDNFRA;RETL1;TRNR1;GDNF family receptor alpha-1;GDNF receptor alpha-1;GDNFR-alpha-1;GFR-alpha-1;RET ligand 1;TGF-beta-related neurotrophic factor receptor 1
Organism-1: Human
Gene ID-1: 2674
SwissProt-1: P56159
Organism-2: Mouse
Gene ID-2: 14585
SwissProt-2: P97785
Organism-3: Rat
Gene ID-3: 25454
SwissProt-3: Q62997
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor . Golgi apparatus, trans-Golgi network . Endosome . Endosome, multivesicular body . Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies. .