U-Blot® JMY Polyclonal Antibody

Name: U-Blot® JMY Polyclonal Antibody
SKU: WP12892
Availability: InStock

$268.00

Size:50μL

SKU: WP12892-50

Catalog No.: WP12892

Specification: 50μL/100μL

Stock: In stock

U-Blot® JMY Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：function:Cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage.,induction:By E2F.,PTM:Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response.,similarity:Contains 1 WH2 domain.,subunit:Interacts with p300/EP300, the complex being recruited to activated p53/TP53. Interacts with TTC5.,

Product Overview

Catalog No.: WP12892
SKU: WP12892-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: JMY
Reactivity: Human,Mouse
Application: WB,ELISA,IHC
MW(Calculated): --
MW(Observed): 130kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human JMY. AA range:931-980
Sequence: --
Specificity: JMY Polyclonal Antibody detects endogenous levels of JMY protein.
Gene Name: JMY
Protein Name: Junction-mediating and -regulatory protein
Other Name: JMY;Junction-mediating and -regulatory protein
Organism-1: Human
Gene ID-1: 133746
SwissProt-1: Q8N9B5
Organism-2: Mouse
Gene ID-2: 57748
SwissProt-2: Q9QXM1
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Cytoplasmic vesicle . Cytoplasm, cytoskeleton . Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane . Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity). In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells. Localizes to cytoplasmic vesicles which associate with actin filament and autophagosomal membranes upon starvation-induced autophagy (PubMed:30420355). .