U-Blot® PKN Polyclonal Antibody

Name: U-Blot® PKN Polyclonal Antibody
SKU: WP14026
Availability: InStock

$268.00

Size:50μL

SKU: WP14026-50

Catalog No.: WP14026

Specification: 50μL/100μL

Stock: In stock

U-Blot® PKN Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：protein kinase N1(PKN1) Homo sapiens The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP14026
SKU: WP14026-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: PRK1
Reactivity: Human,Mouse,Rat
Application: WB,IHC
MW(Calculated): --
MW(Observed): 105kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-300
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from the Internal region of human PKN.
Sequence: --
Specificity: PKN Polyclonal Antibody detects endogenous levels of PKN protein.
Gene Name: PKN1
Protein Name: Serine/threonine-protein kinase N1
Other Name: PKN1;PAK1;PKN;PRK1;PRKCL1;Serine/threonine-protein kinase N1;Protease-activated kinase 1;PAK-1;Protein kinase C-like 1;Protein kinase C-like PKN;Protein kinase PKN-alpha;Protein-kinase C-related kinase 1;Serine-threonine protein
Organism-1: Human
Gene ID-1: 5585
SwissProt-1: Q16512
Organism-2: Mouse
Gene ID-2: 320795
SwissProt-2: P70268
Organism-3: Rat
Gene ID-3: 29355
SwissProt-3: Q63433
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Nucleus . Endosome . Cell membrane ; Peripheral membrane protein . Cleavage furrow . Midbody . Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. .