U-Blot® NF2L1 Polyclonal Antibody

Name: U-Blot® NF2L1 Polyclonal Antibody
SKU: WP1411
Availability: InStock

$268.00

Size:50μL

SKU: WP1411-50

Catalog No.: WP1411

Specification: 50μL/100μL

Stock: In stock

U-Blot® NF2L1 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP1411
SKU: WP1411-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: NF2L1
Reactivity: Human,Mouse
Application: WB,ELISA
MW(Calculated): --
MW(Observed): 84kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;ELISA 1:5000-20000
Form: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human protein . at AA range: 90-170
Sequence: --
Specificity: NF2L1 Polyclonal Antibody detects endogenous levels of protein.
Gene Name: NFE2L1 HBZ17 NRF1 TCF11
Protein Name: Nuclear factor erythroid 2-related factor 1 (NF-E2-related factor 1) (NFE2-related factor 1) (Locus control region-factor 1) (Nuclear factor, erythroid derived 2, like 1) (Transcription factor 11) (TCF-11) (Transcription factor HBZ17) (Transcription factor LCR-F1)
Other Name: --
Organism-1: Human
Gene ID-1: 4779
SwissProt-1: Q14494
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q61985
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Endoplasmic reticulum membrane ; Single-pass type III membrane protein . In normal conditions, probably has a single-pass type II membrane protein topology, with the DNA-binding domain facing the endoplasmic reticulum lumen (PubMed:24448410). Following cellular stress, it is rapidly and efficiently retrotranslocated to the cytosolic side of the membrane, a process dependent on p97/VCP, to have a single-pass type III membrane protein topology with the major part of the protein facing the cytosol (PubMed:24448410). Retrotranslocated proteins are normally rapidly degraded by the proteasome and active species do not accumulate (PubMed:24448410). However, retrotranslocated protein NFE2L1 escapes degradation and is cleaved at Leu-104 by DDI2, releasing the protein from the endoplasmic reticulum membrane and forming the transcription factor NRF1 that translocates into the nucleus (PubMed:24448410). .; [Transcription factor NRF1]: Nucleus . Translocates into the nucleus following cleavage of Endoplasmic reticulum membrane sensor NFE2L1 by aspartyl protease DDI2. .