U-Blot® Sgo2 Polyclonal Antibody

Name: U-Blot® Sgo2 Polyclonal Antibody
SKU: WP14463
Availability: InStock

$268.00

Size:50μL

SKU: WP14463-50

Catalog No.: WP14463

Specification: 50μL/100μL

Stock: In stock

U-Blot® Sgo2 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：function:During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis (By similarity). May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the shugoshin family.,subcellular location:In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase.,subunit:Directly interacts with PPP2CA.,

Product Overview

Catalog No.: WP14463
SKU: WP14463-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Sgo2
Reactivity: Human,Mouse
Application: IHC,IF,ELISA
MW(Calculated): 145kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human SGOL2. AA range:681-730
Sequence: --
Specificity: Sgo2 Polyclonal Antibody detects endogenous levels of Sgo2 protein.
Gene Name: SGOL2
Protein Name: Shugoshin-like 2
Other Name: SGOL2;Shugoshin-like 2;Shugoshin-2;Sgo2;Tripin
Organism-1: Human
Gene ID-1: 151246
SwissProt-1: Q562F6
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q7TSY8
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Chromosome, centromere . Chromosome, centromere, kinetochore . During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (By similarity). SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (By similarity). During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity). In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase (PubMed:17485487). Centromeric localization requires the presence of BUB1 and AUKRB (PubMed:17485487). .