U-Blot® WWOX Polyclonal Antibody

Name: U-Blot® WWOX Polyclonal Antibody
SKU: WP15021
Availability: InStock

$268.00

Size:50μL

SKU: WP15021-50

Catalog No.: WP15021

Specification: 50μL/100μL

Stock: In stock

U-Blot® WWOX Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：WWOX (WW domain containing oxidoreductase) encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. WWOX spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of WWOX is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.

Product Overview

Catalog No.: WP15021
SKU: WP15021-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: WWOX
Reactivity: Human,Mouse
Application: WB,IHC,IF,ELISA
MW(Calculated): --
MW(Observed): 47kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human WWOX. AA range:1-50
Sequence: --
Specificity: WWOX Polyclonal Antibody detects endogenous levels of WWOX protein.
Gene Name: WWOX
Protein Name: WW domain-containing oxidoreductase
Other Name: WWOX;FOR;WOX1;WW domain-containing oxidoreductase;Fragile site FRA16D oxidoreductase
Organism-1: Human
Gene ID-1: 51741
SwissProt-1: Q9NZC7
Organism-2: Mouse
Gene ID-2: 80707
SwissProt-2: Q91WL8
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Nucleus . Mitochondrion . Golgi apparatus . Partially localizes to the mitochondria (PubMed:14695174). Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus. .