U-Blot® Cdk4 Polyclonal Antibody

Name: U-Blot® Cdk4 Polyclonal Antibody
SKU: WP15274
Availability: InStock

$268.00

Size:50μL

SKU: WP15274-50

Catalog No.: WP15274

Specification: 50μL/100μL

Stock: In stock

U-Blot® Cdk4 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：cyclin dependent kinase 4(CDK4) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP15274
SKU: WP15274-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Cdk4
Reactivity: Human,Mouse,Rat
Application: IF,WB,IHC,ELISA
MW(Calculated): --
MW(Observed): 35kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: IF 1:50-200;WB 1:500-1:2000;IHC: 1:100-300;ELISA 1:20000;Not yet tested in other applications;
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human CDK4. AA range:1-50
Sequence: --
Specificity: Cdk4 Polyclonal Antibody detects endogenous levels of Cdk4 protein.
Gene Name: CDK4
Protein Name: Cyclin-dependent kinase 4
Other Name: CDK4;Cyclin-dependent kinase 4;Cell division protein kinase 4;PSK-J3
Organism-1: Human
Gene ID-1: 1019
SwissProt-1: P11802
Organism-2: Mouse
Gene ID-2: 12567
SwissProt-2: P30285
Organism-3: Rat
Gene ID-3: 94201
SwissProt-3: P35426
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Nucleus . Nucleus membrane . Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus. .