U-Blot® CYFIP2 Polyclonal Antibody

Name: U-Blot® CYFIP2 Polyclonal Antibody
SKU: WP15749
Availability: InStock

$268.00

Size:50μL

SKU: WP15749-50

Catalog No.: WP15749

Specification: 50μL/100μL

Stock: In stock

U-Blot® CYFIP2 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level).,function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.,induction:By p53.,RNA editing:Partially edited. Editing appears to be brain-specific.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.,subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,

Product Overview

Catalog No.: WP15749
SKU: WP15749-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: CYFIP2
Reactivity: Human,Mouse,Rat
Application: WB,ELISA
MW(Calculated): --
MW(Observed): 150kD,45kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;ELISA 1:10000-20000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from CYFIP2 at AA range: 1171-1220
Sequence: --
Specificity: CYFIP2 Polyclonal Antibody detects endogenous levels of CYFIP2
Gene Name: CYFIP2
Protein Name: CYFIP2
Other Name: Cytoplasmic FMR1-interacting protein 2;p53-inducible protein 121;
Organism-1: Human
Gene ID-1: 26999
SwissProt-1: Q96F07
Organism-2: Mouse
Gene ID-2: 76884
SwissProt-2: Q5SQX6
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Cell junction, synapse, synaptosome . Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity). Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118). .