U-Blot® SQSTM1/p62 rabbit pAb

Name: U-Blot® SQSTM1/p62 rabbit pAb
SKU: WP16924
Availability: InStock

$268.00

Size:50μL

SKU: WP16924-50

Catalog No.: WP16924

Specification: 50μL/100μL

Stock: In stock

U-Blot® SQSTM1/p62 rabbit pAb Learn more

Product details Specifications Q & A Education

Background：This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009],

Product Overview

Catalog No.: WP16924
SKU: WP16924-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: SQSTM1/p62
Reactivity: Human,Mouse,Rat
Application: WB,IF
MW(Calculated): 48kD
MW(Observed): 60kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IF/ICC1:100-500
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human SQSTM
Sequence: --
Specificity: This antibody detects endogenous levels of SQSTM at Human/Mouse/Rat
Gene Name: SQSTM1 ORCA OSIL
Protein Name: SQSTM
Other Name: --
Organism-1: Human
Gene ID-1: 8878
SwissProt-1: Q13501
Organism-2: Mouse
Gene ID-2: 18412
SwissProt-2: Q64337
Organism-3: Rat
Gene ID-3: 113894
SwissProt-3: O08623
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm, cytosol . Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Nucleus, PML body . Cytoplasm, myofibril, sarcomere . In cardiac muscle, localizes to the sarcomeric band (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large amounts in Mallory bodies of alcoholic and nonalcoholic steatohepatitis, hyaline bodies in hepatocellular carcinoma, and in SERPINA1 aggregates. Enriched in Rosenthal fibers of pilocytic astrocytoma. In the cytoplasm, observed in both membrane-free ubiquitin-containing protein aggregates (sequestosomes) and membrane-surrounded autophagosomes. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum. Co-localizes with TRIM5 in cytoplasmic bodies. When nuclear export is blocked by treatment with leptomycin B, accumulates in PML bodies. .