U-Blot® FILA2 rabbit pAb

Name: U-Blot® FILA2 rabbit pAb
SKU: WP16940
Availability: InStock

$268.00

Size:50μL

SKU: WP16940-50

Catalog No.: WP16940

Specification: 50μL/100μL

Stock: In stock

U-Blot® FILA2 rabbit pAb Learn more

Product details Specifications Q & A Education

Background：The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. [provided by RefSeq, Dec 2015],

Product Overview

Catalog No.: WP16940
SKU: WP16940-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: FILA2
Reactivity: Human,Mouse
Application: WB
MW(Calculated): 263kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human FILA2 AA range: 402-452
Sequence: --
Specificity: This antibody detects endogenous levels of FILA2 at Human/Mouse
Gene Name: FLG2 IFPS
Protein Name: FILA2
Other Name: --
Organism-1: Human
Gene ID-1: 388698
SwissProt-1: Q5D862
Organism-2: Mouse
Gene ID-2: 229574
SwissProt-2: Q2VIS4
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Cytoplasmic granule . In the stratum corneum of the epidermis, dispersed diffusely throughout the cytoplasm, while in the stratum granulosum, localized within keratohyalin granules (PubMed:19384417) (PubMed:21531719). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1. .