U-Blot® SGMR1 Polyclonal Antibody

Name: U-Blot® SGMR1 Polyclonal Antibody
SKU: WP1733
Availability: InStock

$268.00

Size:50μL

SKU: WP1733-50

Catalog No.: WP1733

Specification: 50μL/100μL

Stock: In stock

U-Blot® SGMR1 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013],

Product Overview

Catalog No.: WP1733
SKU: WP1733-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: SGMR1
Reactivity: Human,Rat,Mouse
Application: WB,ELISA
MW(Calculated): --
MW(Observed): 24kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;ELISA 1:5000-20000
Form: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human protein . at AA range: 90-170
Sequence: --
Specificity: SGMR1 Polyclonal Antibody detects endogenous levels of protein.
Gene Name: SIGMAR1 OPRS1 SRBP AAG8
Protein Name: Sigma non-opioid intracellular receptor 1 (Aging-associated gene 8 protein) (SR31747-binding protein) (SR-BP) (Sigma 1-type opioid receptor) (SIG-1R) (Sigma1-receptor) (Sigma1R) (hSigmaR1)
Other Name: --
Organism-1: Human
Gene ID-1: 10280
SwissProt-1: Q99720
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: O55242
Organism-3: Rat
Gene ID-3: --
SwissProt-3: Q9R0C9
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus inner membrane . Nucleus outer membrane . Nucleus envelope . Cytoplasmic vesicle . Endoplasmic reticulum membrane . Membrane ; Single-pass membrane protein . Lipid droplet . Cell junction. Cell membrane . Cell projection, growth cone. Cell junction, synapse, postsynaptic density membrane . During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum. Detected on cytoplasmic vesicles during mitosis (PubMed:10406945). Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Accumulation at the endoplasmic reticulum is prominent in alpha-motor neurons of patients with amyotrophic lateral sclerosis (PubMed:23314020). Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding. In motor neurons it is enriched at cholinergic postsynaptic densities (By similarity). .