U-Blot® PCSK9 rabbit pAb

Name: U-Blot® PCSK9 rabbit pAb
SKU: WP17760
Availability: InStock

$268.00

Size:50μL

SKU: WP17760-50

Catalog No.: WP17760

Specification: 50μL/100μL

Stock: In stock

U-Blot® PCSK9 rabbit pAb Learn more

Product details Specifications Q & A Education

Background：cofactor:Calcium.,disease:Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.,enzyme regulation:Inhibited by EGTA.,function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.,PTM:The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.,similarity:Belongs to the peptidase S8 family.,similarity:Contains 1 peptidase S8 domain.,subunit:The precursor protein but not the mature protein may form multimers.,tissue specificity:Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.,

Product Overview

Catalog No.: WP17760
SKU: WP17760-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: PCSK9
Reactivity: Human,Rat,Mouse,
Application: WB,IHC
MW(Calculated): 76kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-300
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human PCSK9
Sequence: --
Specificity: This antibody detects endogenous levels of Human PCSK9
Gene Name: PCSK9 NARC1 PSEC0052
Protein Name: PCSK9
Other Name: Proprotein convertase subtilisin/kexin type 9;Neural apoptosis-regulated convertase 1;NARC-1;Proprotein convertase 9;PC9;Subtilisin/kexin-like protease PC9;
Organism-1: Human
Gene ID-1: 255738
SwissProt-1: Q8NBP7
Organism-2: Mouse
Gene ID-2: 100102
SwissProt-2: Q80W65
Organism-3: Rat
Gene ID-3: 298296
SwissProt-3: P59996
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation.