U-Blot® WWTR1 Polyclonal Antibody

Name: U-Blot® WWTR1 Polyclonal Antibody
SKU: WP2118
Availability: InStock

$268.00

Size:50μL

SKU: WP2118-50

Catalog No.: WP2118

Specification: 50μL/100μL

Stock: In stock

U-Blot® WWTR1 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：domain:Binds to transcription factors via its WW domain.,domain:The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes.,function:Functions as a transcriptional coactivator.,PTM:Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export.,similarity:Contains 1 WW domain.,subcellular location:Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ.,subunit:Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP.,tissue specificity:Highly expressed in kidney, heart, placenta and lung.,

Product Overview

Catalog No.: WP2118
SKU: WP2118-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: WWTR1
Reactivity: Human,Mouse
Application: WB,IHC
MW(Calculated): --
MW(Observed): 50kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;ELISA 1:5000-20000
Form: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from part region of human protein
Sequence: --
Specificity: WWTR1 Polyclonal Antibody detects endogenous levels of protein.
Gene Name: WWTR1 TAZ
Protein Name: WW domain-containing transcription regulator protein 1
Other Name: WW domain-containing transcription regulator protein 1;Transcriptional coactivator with PDZ-binding motif;
Organism-1: Human
Gene ID-1: 25937
SwissProt-1: Q9GZV5
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q9EPK5
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Cytoplasm . Cell membrane . Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies (By similarity). When phosphorylated, is retained in the cytoplasm by YWHAZ (By similarity). Can be retained in the nucleus by MED15 (PubMed:18568018). Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499). At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass (By similarity). .