U-Blot® HUWE1 Polyclonal Antibody

Name: U-Blot® HUWE1 Polyclonal Antibody
SKU: WP2255
Availability: InStock

$268.00

Size:50μL

SKU: WP2255-50

Catalog No.: WP2255

Specification: 50μL/100μL

Stock: In stock

U-Blot® HUWE1 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. [provided by RefSeq, Aug 2013],

Product Overview

Catalog No.: WP2255
SKU: WP2255-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: HUWE1
Reactivity: Human,Mouse
Application: IHC,IF
MW(Calculated): --
MW(Observed): 481kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: IHC 1:50-300;IF 1:50-200
Form: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from part region of human protein
Sequence: --
Specificity: HUWE1 Polyclonal Antibody detects endogenous levels of protein.
Gene Name: HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272
Protein Name: E3 ubiquitin-protein ligase HUWE1 (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Other Name: --
Organism-1: Human
Gene ID-1: 10075
SwissProt-1: Q7Z6Z7
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q7TMY8
Organism-3: Rat
Gene ID-3: --
SwissProt-3: P51593
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Nucleus . Mitochondrion . Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells (By similarity). Recruited to mitochondria following interaction with AMBRA1 (PubMed:30217973). .