U-Blot® MYOC Polyclonal Antibody

Name: U-Blot® MYOC Polyclonal Antibody
SKU: WP2383
Availability: InStock

$268.00

Size:50μL

SKU: WP2383-50

Catalog No.: WP2383

Specification: 50μL/100μL

Stock: In stock

U-Blot® MYOC Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP2383
SKU: WP2383-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: MYOC
Reactivity: Human,Rat,Mouse
Application: WB,ELISA
MW(Calculated): --
MW(Observed): 55kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;ELISA 1:5000-20000
Form: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from part region of human protein
Sequence: --
Specificity: MYOC Polyclonal Antibody detects endogenous levels of protein.
Gene Name: MYOC GLC1A TIGR
Protein Name: Myocilin (Trabecular meshwork-induced glucocorticoid response protein)
Other Name: --
Organism-1: Human
Gene ID-1: 4653
SwissProt-1: Q99972
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: O70624
Organism-3: Rat
Gene ID-3: --
SwissProt-3: Q9R1J4
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Secreted . Golgi apparatus . Cytoplasmic vesicle . Secreted, extracellular space. Secreted, extracellular space, extracellular matrix . Secreted, extracellular exosome . Mitochondrion . Mitochondrion intermembrane space . Mitochondrion inner membrane . Mitochondrion outer membrane . Rough endoplasmic reticulum . Cell projection. Cell projection, cilium . Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum (PubMed:9169133). It is only imported to mitochondria in the trabecular meshwork (PubMed:17516541). Localizes to the Golgi apparatus in Schlemm's canal endothelial cells (PubMed:11053284). Appears in the extracellular space of trabecular meshwork cells by an unconventional mechanism, likely associated with exosome-like vesicles (PubMed:15944158). Localizes in trabecular meshwork extracellular matrix (PubMed:15944158). .; [Myocilin, C-terminal fragment]: Secreted.; [Myocilin, N-terminal fragment]: Endoplasmic reticulum. Remains retained in the endoplasmic reticulum.