U-Blot® SMAD7 Polyclonal Antibody

Name: U-Blot® SMAD7 Polyclonal Antibody
SKU: WP2728
Availability: InStock

$268.00

Size:50μL

SKU: WP2728-50

Catalog No.: WP2728

Specification: 50μL/100μL

Stock: In stock

U-Blot® SMAD7 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],

Product Overview

Catalog No.: WP2728
SKU: WP2728-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: SMAD7
Reactivity: Human,Mouse,Rat,Goat,Sheep
Application: WB,ELISA
MW(Calculated): --
MW(Observed): 46kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;ELISA 1:5000-20000
Form: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from part region of human protein
Sequence: --
Specificity: SMAD7 Polyclonal Antibody detects endogenous levels of protein.
Gene Name: SMAD7 MADH7 MADH8
Protein Name: Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)
Other Name: Mothers against decapentaplegic homolog 7;MAD homolog 7;Mothers against DPP homolog 7;Mothers against decapentaplegic homolog 8;MAD homolog 8;Mothers against DPP homolog 8;SMAD family member 7;SMAD 7;Smad7;hSMAD7;
Organism-1: Human
Gene ID-1: 4092
SwissProt-1: O15105
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: O35253
Organism-3: Rat
Gene ID-3: --
SwissProt-3: O88406
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Cytoplasm . Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). .