U-Blot® ASM Polyclonal Antibody

Name: U-Blot® ASM Polyclonal Antibody
SKU: WP3234
Availability: InStock

$268.00

Size:50μL

SKU: WP3234-50

Catalog No.: WP3234

Specification: 50μL/100μL

Stock: In stock

U-Blot® ASM Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010],

Product Overview

Catalog No.: WP3234
SKU: WP3234-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: ASM
Reactivity: Human,Mouse
Application: WB,ELISA
MW(Calculated): --
MW(Observed): 69kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;ELISA 1:5000-20000
Form: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from part region of human protein
Sequence: --
Specificity: ASM Polyclonal Antibody detects endogenous levels of protein.
Gene Name: SMPD1 ASM
Protein Name: Sphingomyelin phosphodiesterase (Acid sphingomyelinase) (aSMase)
Other Name: --
Organism-1: Human
Gene ID-1: 6609
SwissProt-1: P17405
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q04519
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Lysosome . Lipid droplet . Secreted . The secreted form is induced in a time- and dose-dependent by IL1B and TNF as well as stress and viral infection. This increase of the secreted form seems to be due to exocytosis of the lysosomal form and is Ca(2+)-dependent (PubMed:20807762, PubMed:22573858, PubMed:20530211). Secretion is dependent of phosphorylation at Ser-510 (PubMed:17303575). Secretion is induced by inflammatory mediators such as IL1B, IFNG or TNF as well as infection with bacteria and viruses (PubMed:12563314, PubMed:20807762). .