- Target
- MR1
- Reactivity
- Human,Mouse,Rat
- Application
- WB
- MW(Calculated)
- 38kD
- MW(Observed)
- --
- Host Species
- Rabbit
- Isotype
- IgG
- Conjugate/Modification
- Unmodified
- Modification site
- --
- Recommended Dilution Ratio
- WB 1:500-2000
- Form
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source
- --
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Purity
- --
- storageCondition
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Concentration
- 1 mg/ml
- Clonality
- Polyclonal
- Clone No.
- --
- Immunogen
- Synthesized peptide derived from human MR1
- Sequence
- --
- Specificity
- This antibody detects endogenous levels of MR1 at Human, Mouse,Rat
- Gene Name
- MR1
- Protein Name
- Major histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein)
- Other Name
- --
- Organism-1
- Human
- Gene ID-1
- 3140
- SwissProt-1
- Q95460
- Organism-2
- Mouse
- Gene ID-2
- 15064
- SwissProt-2
- Q8HWB0
- Organism-3
- Rat
- Gene ID-3
- 25119
- SwissProt-3
- O19477
- Organism-4
- --
- gene ID-4
- --
- SwissProt-4
- --
- Cellular Localization
- Cell membrane ; Single-pass type I membrane protein. Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Golgi apparatus membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . In the absence of antigen remains within the endoplasmic reticulum where it acts as a metabolite sensor. Antigen binding triggers trafficking of the ternary complex to the plasma membrane. After presentation, most of these complexes are rapidly internalized and degraded via endocytosis. A small subset recycles via endosomes back to the plasma membrane and may thus acquire and present new antigens that do not efficiently reach the endoplasmic reticulum. .; [Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein . The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway. .; [Isoform 4]: Secreted .