- Target
- PTPRN
- Reactivity
- Human,Rat
- Application
- WB
- MW(Calculated)
- 108kD
- MW(Observed)
- --
- Host Species
- Rabbit
- Isotype
- IgG
- Conjugate/Modification
- Unmodified
- Modification site
- --
- Recommended Dilution Ratio
- WB 1:500-2000
- Form
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source
- --
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Purity
- --
- storageCondition
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Concentration
- 1 mg/ml
- Clonality
- Polyclonal
- Clone No.
- --
- Immunogen
- Synthesized peptide derived from human IA-2/PTPRN
- Sequence
- --
- Specificity
- This antibody detects endogenous levels of IA-2/PTPRN at Human,Rat
- Gene Name
- PTPRN ICA3 ICA512
- Protein Name
- Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2)
- Other Name
- --
- Organism-1
- Human
- Gene ID-1
- 5798
- SwissProt-1
- Q16849
- Organism-2
- Mouse
- Gene ID-2
- --
- SwissProt-2
- Q60673
- Organism-3
- Rat
- Gene ID-3
- 116660
- SwissProt-3
- Q63259
- Organism-4
- --
- gene ID-4
- --
- SwissProt-4
- --
- Cellular Localization
- Membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass type I membrane protein . Perikaryon . Cell projection, axon . Cell junction, synapse . Cell membrane ; Single-pass type I membrane protein . Endosome . Detected on neuronal secretory vesicles, but not on synaptic vesicles. Colocalizes with insulin-containing secretory granules (PubMed:25561468). Primarily detected on secretory vesicle membranes. Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles via the Golgi apparatus membranes. .; [ICA512-transmembrane fragment]: Cytoplasmic vesicle, secretory vesicle membrane .; [ICA512-cleaved cytosolic fragment]: Nucleus .