U-Blot® APPL2 rabbit pAb

Name: U-Blot® APPL2 rabbit pAb
SKU: WP8322
Availability: InStock

$268.00

Size:50μL

SKU: WP8322-50

Catalog No.: WP8322

Specification: 50μL/100μL

Stock: In stock

U-Blot® APPL2 rabbit pAb Learn more

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U-Blot® APPL2 rabbit pAb

Product Overview

Catalog No.: WP8322
SKU: WP8322-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: APPL2
Reactivity: Human,Mouse
Application: WB
MW(Calculated): 73kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human APPL2
Sequence: --
Specificity: This antibody detects endogenous levels of APPL2 at Human, Mouse
Gene Name: APPL2 DIP13B
Protein Name: DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)
Other Name: --
Organism-1: Human
Gene ID-1: 55198
SwissProt-1: Q8NEU8
Organism-2: Mouse
Gene ID-2: 216190
SwissProt-2: Q8K3G9
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Early endosome membrane ; Peripheral membrane protein . Nucleus . Cell membrane . Endosome membrane . Cytoplasm . Cytoplasmic vesicle, phagosome . Cell projection, ruffle . Cell projection, ruffle membrane . Cell membrane . Cytoplasmic vesicle, phagosome membrane . Early endosomal membrane-bound and nuclear (PubMed:15016378). Translocated into the nucleus upon release from endosomal membranes following internalization of EGF (PubMed:15016378). Associates dynamically with cytoplasmic membrane structures that undergo changes in shape, movement, fusion and fission events (PubMed:18034774). PI(4,5)P2 levels are important for membrane association of APPL2 (PubMed:18034774). Absent of endosome in macrophage. Colocalized with RAB31 at early-stage phagosome (By similarity). Localized on macropinosomes in LPS-activated macrophages. Associated with membrane domains in contact with pathogens and pathogen-derived ligands like LPS. First recruited to the ruffles, and accumulates on macropinosomes (By similarity). .