- Target
- HELB
- Reactivity
- Human,Mouse
- Application
- WB
- MW(Calculated)
- 120kD
- MW(Observed)
- --
- Host Species
- Rabbit
- Isotype
- IgG
- Conjugate/Modification
- Unmodified
- Modification site
- --
- Recommended Dilution Ratio
- WB 1:500-2000
- Form
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source
- --
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Purity
- --
- storageCondition
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Concentration
- 1 mg/ml
- Clonality
- Polyclonal
- Clone No.
- --
- Immunogen
- Synthesized peptide derived from human HELB
- Sequence
- --
- Specificity
- This antibody detects endogenous levels of HELB at Human, Mouse
- Gene Name
- HELB
- Protein Name
- DNA helicase B (hDHB) (EC 3.6.4.12)
- Other Name
- --
- Organism-1
- Human
- Gene ID-1
- 92797
- SwissProt-1
- Q8NG08
- Organism-2
- Mouse
- Gene ID-2
- 117599
- SwissProt-2
- Q6NVF4
- Organism-3
- --
- Gene ID-3
- --
- SwissProt-3
- --
- Organism-4
- --
- gene ID-4
- --
- SwissProt-4
- --
- Cellular Localization
- Nucleus . Cytoplasm . Chromosome . Predominantly nuclear (PubMed:15146062). Phosphorylation at Ser-967 by CDK2 during the G1/S transition results in its nuclear export into the cytoplasm as cells approach and progress through S phase (PubMed:15146062). Following DNA damage, recruited to sites of double-strand breaks by the RPA complex (PubMed:26774285). Recruited to chromatin following DNA damage induced by UV irradiation, or camptothecin or hydroxyurea treatment (PubMed:22194613). .