U-Blot® Cdk1/2/3 (phospho Thr14) Polyclonal Antibody

Name: U-Blot® Cdk1/2/3 (phospho Thr14) Polyclonal Antibody
SKU: WP9093
Availability: InStock

$288.00

Size:50μL

SKU: WP9093-50

Catalog No.: WP9093

Specification: 50μL/100μL

Stock: In stock

U-Blot® Cdk1/2/3 (phospho Thr14) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：cyclin dependent kinase 1(CDK1) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],

Product Overview

Catalog No.: WP9093
SKU: WP9093-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: CDK1/CDC2
Reactivity: Human,Mouse,Rat,Monkey
Application: WB,IF,ELISA
MW(Calculated): --
MW(Observed): 34kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human CDK1/CDC2 around the phosphorylation site of Thr14. AA range:1-50
Sequence: --
Specificity: Phospho-Cdk1/2/3 (T14) Polyclonal Antibody detects endogenous levels of Cdk1/2/3 protein only when phosphorylated at T14.
Gene Name: CDK1/CDK2/CDK3
Protein Name: Cyclin-dependent kinase 1/2/3
Other Name: CDK1;CDC2;CDC28A;CDKN1;P34CDC2;Cyclin-dependent kinase 1;CDK1;Cell division control protein 2 homolog;Cell division protein kinase 1;p34 protein kinase;CDK2;CDKN2;Cyclin-dependent kinase 2;Cell division protein kinase 2;p33 pr
Organism-1: Human
Gene ID-1: 1017
SwissProt-1: P06493;P24941;Q00526
Organism-2: Mouse
Gene ID-2: 12534;12566
SwissProt-2: --
Organism-3: Rat
Gene ID-3: 54237
SwissProt-3: P39951;Q63699
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus. Cytoplasm. Mitochondrion . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle. Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.