U-Blot® Cofilin (phospho Ser3) Polyclonal Antibody

Name: U-Blot® Cofilin (phospho Ser3) Polyclonal Antibody
SKU: WP9103
Availability: InStock

$288.00

Size:50μL

SKU: WP9103-50

Catalog No.: WP9103

Specification: 50μL/100μL

Stock: In stock

U-Blot® Cofilin (phospho Ser3) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：cofilin 1(CFL1) Homo sapiens The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004],

Product Overview

Catalog No.: WP9103
SKU: WP9103-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Cofilin
Reactivity: Human,Mouse,Rat
Application: WB,IHC,IF,ELISA
MW(Calculated): --
MW(Observed): 19kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human Cofilin around the phosphorylation site of Ser3. AA range:1-50
Sequence: --
Specificity: Phospho-Cofilin (S3) Polyclonal Antibody detects endogenous levels of Cofilin protein only when phosphorylated at S3.
Gene Name: CFL1
Protein Name: Cofilin-1
Other Name: CFL1;CFL;Cofilin-1;18 kDa phosphoprotein;p18;Cofilin;non-muscle isoform
Organism-1: Human
Gene ID-1: 3716
SwissProt-1: P23528
Organism-2: Mouse
Gene ID-2: 12631
SwissProt-2: P18760
Organism-3: Rat
Gene ID-3: 29271
SwissProt-3: P45592
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus matrix . Cytoplasm, cytoskeleton . Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium . Cell projection, growth cone . Cell projection, axon . Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.