U-Blot® mTOR (phospho Thr2446) Polyclonal Antibody

Name: U-Blot® mTOR (phospho Thr2446) Polyclonal Antibody
SKU: WP9417
Availability: InStock

$288.00

Size:50μL

SKU: WP9417-50

Catalog No.: WP9417

Specification: 50μL/100μL

Stock: In stock

U-Blot® mTOR (phospho Thr2446) Polyclonal Antibody Learn more

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Background：The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008],

Product Overview

Catalog No.: WP9417
SKU: WP9417-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: mTOR
Reactivity: Human,Mouse,Rat
Application: WB,ELISA,IHC
MW(Calculated): --
MW(Observed): 220kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human mTOR around the phosphorylation site of Thr2446. AA range:2412-2461
Sequence: --
Specificity: Phospho-mTOR (T2446) Polyclonal Antibody detects endogenous levels of mTOR protein only when phosphorylated at T2446.
Gene Name: MTOR
Protein Name: Serine/threonine-protein kinase mTOR
Other Name: MTOR;FRAP;FRAP1;FRAP2;RAFT1;RAPT1;Serine/threonine-protein kinase mTOR;FK506-binding protein 12-rapamycin complex-associated protein 1;FKBP12-rapamycin complex-associated protein;Mammalian target of rapamycin;mTOR;Mechanistic tar
Organism-1: Human
Gene ID-1: 2475
SwissProt-1: P42345
Organism-2: Mouse
Gene ID-2: 56717
SwissProt-2: Q9JLN9
Organism-3: Rat
Gene ID-3: 56718
SwissProt-3: P42346
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome . Cytoplasm . Nucleus, PML body . Microsome membrane . Lysosome membrane . Cytoplasmic vesicle, phagosome . Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137). Lysosome targeting also depends on interaction with MEAK7. Translocates to the lysosome membrane in the presence of TM4SF5 (PubMed:30956113). .