U-Blot® Lfc (phospho Ser886) Polyclonal Antibody

Name: U-Blot® Lfc (phospho Ser886) Polyclonal Antibody
SKU: WP9431
Availability: InStock

$288.00

Size:50μL

SKU: WP9431-50

Catalog No.: WP9431

Specification: 50μL/100μL

Stock: In stock

U-Blot® Lfc (phospho Ser886) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009],

Product Overview

Catalog No.: WP9431
SKU: WP9431-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Lfc
Reactivity: Human,Mouse,Rat
Application: WB,IHC,IF,ELISA
MW(Calculated): --
MW(Observed): 111kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human Rho/Rac Guanine Nucleotide Exchange Factor 2 around the phosphorylation site of Ser885. AA range:851-900
Sequence: --
Specificity: Phospho-Lfc (S885) Polyclonal Antibody detects endogenous levels of Lfc protein only when phosphorylated at S885.
Gene Name: ARHGEF2
Protein Name: Rho guanine nucleotide exchange factor 2
Other Name: ARHGEF2;KIAA0651;LFP40;Rho guanine nucleotide exchange factor 2;Guanine nucleotide exchange factor H1;GEF-H1;Microtubule-regulated Rho-GEF;Proliferating cell nucleolar antigen p40
Organism-1: Human
Gene ID-1: 9181
SwissProt-1: Q92974
Organism-2: Mouse
Gene ID-2: 16800
SwissProt-2: Q60875
Organism-3: Rat
Gene ID-3: 310635
SwissProt-3: Q5FVC2
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm, cytoskeleton . Cytoplasm . Cell junction, tight junction . Golgi apparatus . Cytoplasm, cytoskeleton, spindle . Cell projection, ruffle membrane . Cytoplasmic vesicle . Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization (PubMed:15827085). Recruited into membrane ruffles induced by S.flexneri at tight junctions of polarized epithelial cells (PubMed:19043560). Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (PubMed:21887730). .