U-Blot® SIRT1 (phospho Ser47) Polyclonal Antibody

Name: U-Blot® SIRT1 (phospho Ser47) Polyclonal Antibody
SKU: WP9521
Availability: InStock

$288.00

Size:50μL

SKU: WP9521-50

Catalog No.: WP9521

Specification: 50μL/100μL

Stock: In stock

U-Blot® SIRT1 (phospho Ser47) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008],

Product Overview

Catalog No.: WP9521
SKU: WP9521-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: SIRT1
Reactivity: Human,Mouse
Application: WB,ELISA,IHC
MW(Calculated): --
MW(Observed): 85-110kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized phospho-peptide around the phosphorylation site of human SIRT1 (phospho Ser47)
Sequence: --
Specificity: Phospho-SIRT1 (S47) Polyclonal Antibody detects endogenous levels of SIRT1 protein only when phosphorylated at S47.
Gene Name: SIRT1
Protein Name: NAD-dependent protein deacetylase sirtuin-1
Other Name: SIRT1;SIR2L1;NAD-dependent protein deacetylase sirtuin-1;hSIRT1;Regulatory protein SIR2 homolog 1;SIR2-like protein 1;hSIR2
Organism-1: Human
Gene ID-1: 23411
SwissProt-1: Q96EB6
Organism-2: Mouse
Gene ID-2: 93759
SwissProt-2: Q923E4
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus, PML body . Cytoplasm . Nucleus . Recruited to the nuclear bodies via its interaction with PML (PubMed:12006491). Colocalized with APEX1 in the nucleus (PubMed:19934257). May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane (PubMed:15469825). Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). .; [SirtT1 75 kDa fragment]: Cytoplasm . Mitochondrion .