U-Blot® Hck (phospho Tyr521) Polyclonal Antibody

Name: U-Blot® Hck (phospho Tyr521) Polyclonal Antibody
SKU: WP9526
Availability: InStock

$288.00

Size:50μL

SKU: WP9526-50

Catalog No.: WP9526

Specification: 50μL/100μL

Stock: In stock

U-Blot® Hck (phospho Tyr521) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010],

Product Overview

Catalog No.: WP9526
SKU: WP9526-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Hck
Reactivity: Human,Mouse,Rat
Application: WB,ELISA
MW(Calculated): --
MW(Observed): 60kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Hck (phospho Tyr521)
Sequence: --
Specificity: Phospho-Hck (Y521) Polyclonal Antibody detects endogenous levels of Hck protein only when phosphorylated at Y521.
Gene Name: HCK
Protein Name: Tyrosine-protein kinase HCK
Other Name: HCK;Tyrosine-protein kinase HCK;Hematopoietic cell kinase;Hemopoietic cell kinase;p59-HCK/p60-HCK;p59Hck;p61Hck
Organism-1: Human
Gene ID-1: 3055
SwissProt-1: P08631
Organism-2: Mouse
Gene ID-2: 15162
SwissProt-2: P08103
Organism-3: Rat
Gene ID-3: 25734
SwissProt-3: P50545
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: [Isoform 1]: Lysosome. Membrane; Lipid-anchor. Cell projection, podosome membrane; Lipid-anchor. Cytoplasm, cytosol. Associated with specialized secretory lysosomes called azurophil granules. At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated.; [Isoform 2]: Cell membrane ; Lipid-anchor . Membrane, caveola ; Lipid-anchor . Cell junction, focal adhesion . Cytoplasm, cytoskeleton . Golgi apparatus . Cytoplasmic vesicle . Lysosome . Nucleus . 20% of this isoform is associated with caveolae. Localization at the cell membrane and at caveolae requires palmitoylation at Cys-3. Colocalizes with the actin cytoskeleton at focal adhesions.; Cytoplasmic vesicle, secretory vesicle. Cytoplasm, cytosol.