U-Blot® ARK-1 (phospho Thr288) Polyclonal Antibody

Name: U-Blot® ARK-1 (phospho Thr288) Polyclonal Antibody
SKU: WP9677
Availability: InStock

$288.00

Size:50μL

SKU: WP9677-50

Catalog No.: WP9677

Specification: 50μL/100μL

Stock: In stock

U-Blot® ARK-1 (phospho Thr288) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP9677
SKU: WP9677-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: ARK-1
Reactivity: Human,Mouse,Rat
Application: WB,IHC,IF,ELISA
MW(Calculated): --
MW(Observed): 45kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human Aurora Kinase around the phosphorylation site of Thr288. AA range:256-305
Sequence: --
Specificity: Phospho-ARK-1 (T288) Polyclonal Antibody detects endogenous levels of ARK-1 protein only when phosphorylated at T288.
Gene Name: AURKA
Protein Name: Aurora kinase A
Other Name: AURKA;AIK;AIRK1;ARK1;AURA;AYK1;BTAK;IAK1;STK15;STK6;Aurora kinase A;Aurora 2;Aurora/IPL1-related kinase 1;ARK-1;Aurora-related kinase 1;hARK1;Breast tumor-amplified kinase;Serine/threonine-protein kinase 15;Serine/threonin
Organism-1: Human
Gene ID-1: 6790
SwissProt-1: O14965
Organism-2: Mouse
Gene ID-2: 20878
SwissProt-2: P97477
Organism-3: Rat
Gene ID-3: --
SwissProt-3: P59241
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, neuron projection . Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). The localization to the spindle poles is regulated by AAAS (PubMed:26246606). .