U-Blot® Pin1 (phospho Ser16) Polyclonal Antibody

Name: U-Blot® Pin1 (phospho Ser16) Polyclonal Antibody
SKU: WP9734
Availability: InStock

$288.00

Size:50μL

SKU: WP9734-50

Catalog No.: WP9734

Specification: 50μL/100μL

Stock: In stock

U-Blot® Pin1 (phospho Ser16) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011],

Product Overview

Catalog No.: WP9734
SKU: WP9734-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Pin1
Reactivity: Human,Mouse,Rat,Monkey
Application: WB,IHC,IF,ELISA
MW(Calculated): --
MW(Observed): 18kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human Pin1 around the phosphorylation site of Ser16. AA range:1-50
Sequence: --
Specificity: Phospho-Pin1 (S16) Polyclonal Antibody detects endogenous levels of Pin1 protein only when phosphorylated at S16.
Gene Name: PIN1
Protein Name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Other Name: PIN1;Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1;Peptidyl-prolyl cis-trans isomerase Pin1;PPIase Pin1;Rotamase Pin1
Organism-1: Human
Gene ID-1: 5300
SwissProt-1: Q13526
Organism-2: Mouse
Gene ID-2: 23988
SwissProt-2: Q9QUR7
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Nucleus speckle . Cytoplasm . Colocalizes with NEK6 in the nucleus (PubMed:16476580). Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization (PubMed:21497122). .