U-Blot® YAP (phospho Ser127) Polyclonal Antibody

Name: U-Blot® YAP (phospho Ser127) Polyclonal Antibody
SKU: WP9740
Availability: InStock

$288.00

Size:50μL

SKU: WP9740-50

Catalog No.: WP9740

Specification: 50μL/100μL

Stock: In stock

U-Blot® YAP (phospho Ser127) Polyclonal Antibody Learn more

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Background：This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013],

Product Overview

Catalog No.: WP9740
SKU: WP9740-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: YAP
Reactivity: Human,Mouse,Rat,Monkey
Application: IF,WB,IHC,ELISA
MW(Calculated): --
MW(Observed): 65kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: IF 1:50-200;WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;Not yet tested in other applications;
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human YAP around the phosphorylation site of Ser127. AA range:93-142
Sequence: --
Specificity: Phospho-YAP (S127) Polyclonal Antibody detects endogenous levels of YAP protein only when phosphorylated at S127.
Gene Name: YAP1
Protein Name: Yorkie homolog
Other Name: YAP1;YAP65;Yorkie homolog;65 kDa Yes-associated protein;YAP65
Organism-1: Human
Gene ID-1: 10413
SwissProt-1: P46937
Organism-2: Mouse
Gene ID-2: 22601
SwissProt-2: P46938
Organism-3: Rat
Gene ID-3: 363014
SwissProt-3: Q2EJA0
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Nucleus . Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288, PubMed:20048001). Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288, PubMed:20048001). At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001, PubMed:25849865). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). .