U-Blot® PKR (phospho Thr258) Polyclonal Antibody

Name: U-Blot® PKR (phospho Thr258) Polyclonal Antibody
SKU: WP9828
Availability: InStock

$288.00

Size:50μL

SKU: WP9828-50

Catalog No.: WP9828

Specification: 50μL/100μL

Stock: In stock

U-Blot® PKR (phospho Thr258) Polyclonal Antibody Learn more

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Background：The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Product Overview

Catalog No.: WP9828
SKU: WP9828-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: PKR
Reactivity: Human,Rat,Mouse,
Application: WB,IHC,IF,ELISA
MW(Calculated): --
MW(Observed): 62kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human PKR around the phosphorylation site of Thr258. AA range:226-275
Sequence: --
Specificity: Phospho-PKR (T258) Polyclonal Antibody detects endogenous levels of PKR protein only when phosphorylated at T258.
Gene Name: EIF2AK2
Protein Name: Interferon-induced double-stranded RNA-activated protein kinase
Other Name: EIF2AK2;PKR;PRKR;Interferon-induced;double-stranded RNA-activated protein kinase;Eukaryotic translation initiation factor 2-alpha kinase 2;eIF-2A protein kinase 2;Interferon-inducible RNA-dependent protein kinase;P1/eIF-2A protein k
Organism-1: Human
Gene ID-1: 5610
SwissProt-1: P19525
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q03963
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Nuclear localization is elevated in acute leukemia, myelodysplastic syndrome (MDS), melanoma, breast, colon, prostate and lung cancer patient samples or cell lines as well as neurocytes from advanced Creutzfeldt-Jakob disease patients. .