U-Blot® Separase (phospho Ser801) Polyclonal Antibody

Name: U-Blot® Separase (phospho Ser801) Polyclonal Antibody
SKU: WP9903
Availability: InStock

$288.00

Size:50μL

SKU: WP9903-50

Catalog No.: WP9903

Specification: 50μL/100μL

Stock: In stock

U-Blot® Separase (phospho Ser801) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010],

Product Overview

Catalog No.: WP9903
SKU: WP9903-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Separase
Reactivity: Human,Mouse
Application: WB,IHC,IF,ELISA
MW(Calculated): --
MW(Observed): 230kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:40000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human SEPARASE around the phosphorylation site of Ser801. AA range:767-816
Sequence: --
Specificity: Phospho-Separase (S801) Polyclonal Antibody detects endogenous levels of Separase protein only when phosphorylated at S801.
Gene Name: ESPL1
Protein Name: Separin
Other Name: ESPL1;ESP1;KIAA0165;Separin;Caspase-like protein ESPL1;Extra spindle poles-like 1 protein;Separase
Organism-1: Human
Gene ID-1: 9700
SwissProt-1: Q14674
Organism-2: Mouse
Gene ID-2: 105988
SwissProt-2: P60330
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm. Nucleus.