U-Blot® IRF-3 (phospho Ser385) Polyclonal Antibody

Name: U-Blot® IRF-3 (phospho Ser385) Polyclonal Antibody
SKU: WP9911
Availability: InStock

$288.00

Size:50μL

SKU: WP9911-50

Catalog No.: WP9911

Specification: 50μL/100μL

Stock: In stock

U-Blot® IRF-3 (phospho Ser385) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],

Product Overview

Catalog No.: WP9911
SKU: WP9911-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: IRF-3
Reactivity: Human,Rat,Mouse,
Application: WB,IHC,IF,ELISA
MW(Calculated): --
MW(Observed): 48-55kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human IRF-3 around the phosphorylation site of Ser385. AA range:351-400
Sequence: --
Specificity: Phospho-IRF-3 (S385) Polyclonal Antibody detects endogenous levels of IRF-3 protein only when phosphorylated at S385.
Gene Name: IRF3
Protein Name: Interferon regulatory factor 3
Other Name: IRF3;Interferon regulatory factor 3;IRF-3
Organism-1: Human
Gene ID-1: 3661
SwissProt-1: Q14653
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: P70671
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Nucleus . Mitochondrion . Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). .