U-Blot® AR-β2 (phospho Ser346) Polyclonal Antibody

Name: U-Blot® AR-β2 (phospho Ser346) Polyclonal Antibody
SKU: WP9973
Availability: InStock

$288.00

Size:50μL

SKU: WP9973-50

Catalog No.: WP9973

Specification: 50μL/100μL

Stock: In stock

U-Blot® AR-β2 (phospho Ser346) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP9973
SKU: WP9973-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Adrenergic Receptor β2
Reactivity: Human,Rat,Mouse,
Application: WB,IHC,IF,ELISA
MW(Calculated): --
MW(Observed): 40kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human Adrenergic Receptor beta2 around the phosphorylation site of Ser346. AA range:321-370
Sequence: --
Specificity: Phospho-AR-β2 (S346) Polyclonal Antibody detects endogenous levels of AR-β2 protein only when phosphorylated at S346.
Gene Name: ADRB2
Protein Name: Beta-2 adrenergic receptor
Other Name: ADRB2;ADRB2R;B2AR;Beta-2 adrenergic receptor;Beta-2 adrenoreceptor;Beta-2 adrenoceptor
Organism-1: Human
Gene ID-1: 154
SwissProt-1: P07550
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: P18762
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cell membrane ; Multi-pass membrane protein . Early endosome . Golgi apparatus . Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). Activated receptors are also detected within the Golgi apparatus (PubMed:27481942). .