U-Blot® SMAD2 (Phospho Ser465/467) Rabbit mAb

U-Blot® SMAD2 (Phospho Ser465/467) Rabbit mAb
U-Blot® SMAD2 (Phospho Ser465/467) Rabbit mAb
$288.00
Size:50μL
SKU: WR4508-50

Catalog No.: WR4508

Specification: 50μL/100μL

Stock: In stock

U-Blot® SMAD2 (Phospho Ser465/467) Rabbit mAb Learn more

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Product information

Product detailsSpecificationsQ & AEducation

Background：The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation

Product Overview

Catalog No.
WR4508
SKU
WR4508-50
Category
Rabbit mAbs
Product Type
Other
Size
50μL/100μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only
Yes

Additional Specifications

Target
Smad2
Reactivity
Human,Mouse,Rat
Application
WB,IF,ELISA
MW(Calculated)
52kD
MW(Observed)
60kD
Host Species
Rabbit
Isotype
IgG,Kappa
Conjugate/Modification
Phospho
Modification site
--
Recommended Dilution Ratio
WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
Form
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
--
Purification
Protein A
Purity
--
storageCondition
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
--
Clonality
--
Clone No.
PT0662R
Immunogen
--
Sequence
--
Specificity
Smad2 (Phospho Ser465/467) Antibody detects endogenous levels of Smad2 protein only when phosphorylated at Ser465/Ser467.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):CSsMs
Gene Name
SMAD2 MADH2 MADR2
Protein Name
Smad2 (Ser465/467)
Other Name
Mothers against decapentaplegic homolog 2;MAD homolog 2;Mothers against DPP homolog 2;JV18-1;Mad-related protein 2;hMAD-2;SMAD family member 2;SMAD 2;Smad2;hSMAD2;
Organism-1
Human
Gene ID-1
4087
SwissProt-1
Q15796
Organism-2
Mouse
Gene ID-2
17126
SwissProt-2
Q62432
Organism-3
Rat
Gene ID-3
29357
SwissProt-3
O70436
Organism-4
--
gene ID-4
--
SwissProt-4
--
Cellular Localization
Cytoplasm . Nucleus . Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696, PubMed:21145499). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). .

Tech Support

ucallm

01

Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

02

Storage & Handling

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
06

Contact Support

Emailinfo@ucallmlabs.com

Phone+(1)-866-986-9598

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Keywords:Rabbit mAbs