U-Blot® p130 Cas Rabbit mAb

U-Blot® p130 Cas Rabbit mAb
U-Blot® p130 Cas Rabbit mAb
$268.00
Size:50μL
SKU: WR4844-50

Catalog No.: WR4844

Specification: 50μL/100μL

Stock: In stock

U-Blot® p130 Cas Rabbit mAb Learn more

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Product information

Product detailsSpecificationsQ & AEducation

Background：BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009],

Product Overview

Catalog No.
WR4844
SKU
WR4844-50
Category
Rabbit mAbs
Product Type
Other
Size
50μL/100μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only
Yes

Additional Specifications

Target
p130 Cas
Reactivity
Human,Mouse,Rat
Application
WB,IF,ELISA
MW(Calculated)
93kD
MW(Observed)
130kD
Host Species
Rabbit
Isotype
IgG,Kappa
Conjugate/Modification
Unmodified
Modification site
--
Recommended Dilution Ratio
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
Form
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
--
Purification
Protein A
Purity
--
storageCondition
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
--
Clonality
Monoclonal
Clone No.
PT0961R
Immunogen
--
Sequence
--
Specificity
Endogenous
Gene Name
BCAR1
Protein Name
Breast cancer anti-estrogen resistance protein 1
Other Name
BCAR1;CAS;CASS1;CRKAS;Breast cancer anti-estrogen resistance protein 1;CRK-associated substrate;Cas scaffolding protein family member 1;p130cas
Organism-1
Human
Gene ID-1
9564
SwissProt-1
P56945
Organism-2
Mouse
Gene ID-2
12927
SwissProt-2
Q61140
Organism-3
Rat
Gene ID-3
25414
SwissProt-3
Q63767
Organism-4
--
gene ID-4
--
SwissProt-4
--
Cellular Localization
Domain:A serine-rich region promotes activation of the serum response element (SRE).,Domain:Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with CASL.,Domain:The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of focal adhesion kinase 1.,Function:Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.,PTM:Focal adhesion kinase 1 phosphorylates the protein at the YDYVHL motif. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix.,similarity:Belongs to the CAS family.,similarity:Contains 1 SH3 domain.,subcellular location:Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.,subunit:Forms complexes in vivo with focal adhesion kinase 1, adapter protein CRKL and LYN kinase. Can heterodimerize with CASL. Interacts with BCAR3, NPHP1, PTK2B and SH2D3C (By similarity). Interacts with activated CSPG4. Interacts with INPPL1/SHIP2.,tissue specificity:Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.,

Tech Support

ucallm

01

Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

02

Storage & Handling

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
06

Contact Support

Emailinfo@ucallmlabs.com

Phone+(1)-866-986-9598

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Keywords:Rabbit mAbs