U-Blot® HMGA2 Rabbit mAb

U-Blot® HMGA2 Rabbit mAb
U-Blot® HMGA2 Rabbit mAb
$268.00
Size:50μL
SKU: WR4942-50

Catalog No.: WR4942

Specification: 50μL/100μL

Stock: In stock

U-Blot® HMGA2 Rabbit mAb Learn more

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Product information

Product detailsSpecificationsQ & AEducation

Background：This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.
WR4942
SKU
WR4942-50
Category
Rabbit mAbs
Product Type
Other
Size
50μL/100μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only
Yes

Additional Specifications

Target
HMGA2
Reactivity
Human,Rat
Application
WB,IHC,IF,ELISA
MW(Calculated)
12kD
MW(Observed)
18kD
Host Species
Rabbit
Isotype
IgG,Kappa
Conjugate/Modification
Unmodified
Modification site
--
Recommended Dilution Ratio
IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
Form
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
--
Purification
Protein A
Purity
--
storageCondition
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
--
Clonality
Monoclonal
Clone No.
PT1165R
Immunogen
--
Sequence
--
Specificity
Endogenous
Gene Name
HMGA2 HMGIC
Protein Name
High mobility group protein HMGI-C (High mobility group AT-hook protein 2)
Other Name
--
Organism-1
Human
Gene ID-1
8091
SwissProt-1
P52926
Organism-2
Mouse
Gene ID-2
--
SwissProt-2
P52927
Organism-3
--
Gene ID-3
--
SwissProt-3
--
Organism-4
--
gene ID-4
--
SwissProt-4
--
Cellular Localization
developmental stage:Expressed predominantly during embryogenesis.,Disease:A chromosomal aberration involving HMGA2 is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with LPP is shown in lipomas. HMGA2 is also fused with a number of other genes in lipomas.,Disease:A chromosomal aberration involving HMGA2 is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with LPP is also shown in one parosteal lipoma.,Disease:A chromosomal aberration involving HMGA2 is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with LPP is detected in pulmonary chondroid hamartomas.,Disease:A chromosomal aberration involving HMGA2 is found in uterine leiomyoma (UL) [MIM:150699]. Translocation t(12;14)(q15;q23-24) with RAD51L1. Chromosomal rearrangements involving HMGA2 do not seem to be the principle pathobiological mechanism in uterine leiomyoma.,Function:Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2.,polymorphism:Genetic variation in HMGA2 has been associated with stature as a quantitative trait (STQTL9) [MIM:611547]. Human height is a classic, highly heritable quantitative trait.,PTM:Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity.,similarity:Belongs to the HMGA family.,similarity:Contains 3 A.T hook DNA-binding domains.,subunit:Interacts with E4F1.,

Tech Support

ucallm

01

Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

02

Storage & Handling

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
06

Contact Support

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Keywords:Rabbit mAbs