U-Blot® N WASP Rabbit mAb

U-Blot® N WASP Rabbit mAb
U-Blot® N WASP Rabbit mAb
$268.00
Size:50μL
SKU: WR4979-50

Catalog No.: WR4979

Specification: 50μL/100μL

Stock: In stock

U-Blot® N WASP Rabbit mAb Learn more

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Product information

Product detailsSpecificationsQ & AEducation

Background：This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013],

Product Overview

Catalog No.
WR4979
SKU
WR4979-50
Category
Rabbit mAbs
Product Type
Other
Size
50μL/100μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only
Yes

Additional Specifications

Target
N WASP
Reactivity
Human,Mouse,Rat
Application
WB,IHC,IF,ELISA
MW(Calculated)
55kD
MW(Observed)
65kD
Host Species
Rabbit
Isotype
IgG,Kappa
Conjugate/Modification
Tyr525/526
Modification site
--
Recommended Dilution Ratio
IHC 1:100-1:500;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
Form
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
--
Purification
Protein A
Purity
--
storageCondition
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
--
Clonality
Monoclonal
Clone No.
PT1211R
Immunogen
--
Sequence
--
Specificity
Endogenous
Gene Name
WASL
Protein Name
Neural Wiskott-Aldrich syndrome protein (N-WASP)
Other Name
--
Organism-1
Human
Gene ID-1
8976
SwissProt-1
O00401
Organism-2
Mouse
Gene ID-2
--
SwissProt-2
Q91YD9
Organism-3
Rat
Gene ID-3
--
SwissProt-3
O08816
Organism-4
--
gene ID-4
--
SwissProt-4
--
Cellular Localization
Function:Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.,similarity:Contains 1 CRIB domain.,similarity:Contains 1 WH1 domain.,similarity:Contains 2 WH2 domains.,subcellular location:Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated.,subunit:Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP. Interacts with the WW domains of PRPF40A/FBP11 (By similarity). Interacts with NOSTRIN. Interacts with Shigella flexneri protein icsA. The interaction with icsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly.,

Tech Support

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

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Storage & Handling

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
06

Contact Support

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Keywords:Rabbit mAbs